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Drugs aim to make cancers self-destruct

- New medicines go after an aberration involving a disease gene fundamental to tumour growth

Dec. 25: For the first time ever, three pharmaceutical companies are poised to test whether new drugs can work against a wide range of cancers independently of where they originated — breast, prostate, liver, lung.

The drugs go after an aberration involving a cancer gene fundamental to tumour growth. Many scientists see this as the beginning of a new genetic age in cancer research.

Great uncertainties remain, but such drugs could mean new treatments for rare, neglected cancers, as well as common ones. Merck, Roche and Sanofi are racing to develop their own versions of a drug they hope will restore a mechanism that normally makes badly damaged cells self-destruct and could potentially be used against half of all cancers.

No pharmaceutical company has ever conducted a major clinical trial of a drug in patients who have many different kinds of cancer, researchers and federal regulators say. “This is a taste of the future in cancer drug development,” said Dr Otis Webb Brawley, the chief medical and scientific officer of the American Cancer Society. “I expect the organ from which the cancer came from will be less important in the future and the molecular target more important,” he added.

And this has major implications for cancer philanthropy, experts say. Advocacy groups should shift from fund-raising for particular cancers to pushing for research aimed at many kinds of cancer at once, Dr Brawley said. John Walter, the chief executive officer of the Leukemia and Lymphoma Society, concurred, saying that by pooling forces “our strength can be leveraged”.

At the heart of this search for new cancer drugs are patients like Joe Bellino, who was a post office clerk until his cancer made him too sick to work. Seven years ago, he went into the hospital for hernia surgery, only to learn he had liposarcoma, a rare cancer of fat cells. A large tumour was wrapped around a cord that connects the testicle to the abdomen. “I was shocked,” he said in an interview this summer.

Companies have long ignored liposarcoma, seeing no market for drugs to treat a cancer that strikes so few. But it is ideal for testing Sanofi’s drug because the tumours nearly always have the exact genetic problem the drug was meant to attack — a fusion of two large proteins.

If the drug works, it should bring these raging cancers to a halt. Then Sanofi would test the drug on a broad range of cancers with a similar genetic alteration. But if the drug fails against liposarcoma, Sanofi will reluctantly admit defeat.

“For us, this is a go/no-go situation,” said Laurent Debussche, a Sanofi scientist who leads the company’s research on the drug.

The genetic alteration the drug targets has tantalised researchers for decades. Normal healthy cells have a mechanism that tells them to die if their DNA is too badly damaged to repair.

Cancer cells have grotesquely damaged DNA, so ordinarily they would self-destruct. A protein known as p53 that Dr Gary Gilliland of Merck calls the cell’s angel of death normally sets things in motion. But cancer cells disable p53, either directly, with a mutation, or indirectly, by attaching the p53 protein to another cellular protein that blocks it. The dream of cancer researchers has long been to reanimate p53 in cancer cells so they will die on their own.

The p53 story began in earnest about 20 years ago. Excitement ran so high that, in 1993, Science magazine anointed it Molecule of the Year and put it on the cover. An editorial held out the possibility of “a cure of a terrible killer in the not too distant future”.

Companies began chasing a drug to restore p53 in cells where it was disabled by mutations. But while scientists know how to block genes, they have not figured out how to add or restore them. Researchers tried gene therapy, adding good copies of the p53 gene to cancer cells. That did not work.

Then, instead of going after mutated p53 genes, they went after half of cancers that used the alternative route to disable p53, blocking it by attaching it to a protein known as MDM2. When the two proteins stick together, the p53 protein no longer functions. Maybe, researchers thought, they could find a molecule to wedge itself between the two proteins and pry them apart.

The problem was that both proteins are huge and cling tightly to each other. Drug molecules are typically tiny. How could they find one that could separate these two bruisers, like a referee at a boxing match?

In 1996, researchers at Roche noticed a small pocket between the behemoths where a tiny molecule might slip in and pry them apart. It took six years, but Roche found such a molecule and named it Nutlin because the lab was in Nutley, New Jersey. But Nutlins did not work as drugs because they were not absorbed into the body.

Roche, Merck and Sanofi persevered, testing thousands of molecules. At Sanofi, the stubborn scientist leading the way, Dr Debussche, maintained an obsession with p53 for two decades. Finally, in 2009, his team, together with Shaomeng Wang at the University of Michigan and a biotech company, Ascenta Therapeutics, found a promising compound.

The company tested the drug by pumping it each day into the stomachs of mice with sarcoma.

A week later, Cedric Barriere, the scientist conducting the experiment, went to his boss, Dr Debussche, saying: “Laurent, I have a problem.” He confessed that he had treated some of the mice only once. And their tumours had vanished. Dr Debussche was stunned. “We have to reproduce it,” he said. They did.

Dr Debussche popped open a bottle of Champagne, but his team tempered its hope. “The joke is if we were trying to cure mouse cancer we would have done it 30 years ago,” said Dr Donald Bergstrom, a vice- president at Sanofi.

As research progressed, all three companies worried about the unprecedented challenges of testing a drug in many types of cancers at once. Such a clinical trial would most likely involve just a few patients in each of many medical centres. But keeping a trial going involves mounds of paperwork and documentation. Medical centres are often loath to do it for just a handful of patients.

Roche was the first to start testing a p53 drug in patients. The company began, as required, with an attempt to establish a dose strong enough to be effective but not too toxic. It took a surprisingly long time — three years — because Roche was cautious, starting with a tiny dose and gradually escalating it.

Health authorities in the US and Europe worried that the medicines might have unexpected effects. “Drugs of this type had never been given to a human being,” Dr Gwen Nichols of Roche said.

The studies looked only at safety, but Dr Nichols said there were encouraging hints that the drugs might be working. In biopsies and scans, cancer cells appeared to be dying. Rigorous efficacy studies are next.

If they are successful, they will be followed by clinical trials across cancer types.

More recently, Merck began its study to find a safe dose. It is enrolling only patients with acute myelogenous leukemia, a cancer in which p53 is almost always disabled by the blocking protein MDM2.

Once the company finds the best dose, it plans to give its drug to just 15 to 30 patients and look for efficacy. And if the drug fails to break apart the two huge proteins and enable the angel of death to do its job? “Then we will not bring the drug forward,” Dr Gilliland said.

Sanofi is in much the same position. It just started its safety tests in Europe. Medical centres in the US will be added next year. Like Merck, it will focus solely on patients who are most likely to respond to its own drug — in this case, patients with liposarcoma like Bellino.

Their tumours can be as big as a watermelon, says Dr Andrew J. Wagner, an expert at the Dana-Farber Cancer Institute and one of Bellino’s doctors.

They often start at the back of a patient’s belly, where they go unnoticed unless the person is very thin. “There is a lot of space back there,” Dr Wagner explained. Surgeons try to remove the tumours, but they usually grow back and spread.

Liposarcoma is so rare — only about 2,000 or so cases each year — that no drugs have ever been specifically tested on patients with this type of cancer. Bellino said over the summer that he hoped he could be among the first to try it. When the call goes out for study subjects, he said, “I will be waving my hands.”

But the test will come too late for him. He died from his cancer on November 13.

 
 
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